After years of development, William Krause knew that 2014 was the year to “go big or go home.” His Flexible Herbert Screw, a medical device intended to support the healing of fractured collarbones (clavicles), was ready for launch, and he had accumulated the necessary cash—$1 million by his reckoning—needed to comfortably see him through the start-up phase. Although evidence in favor of the invasive device was still inconclusive, other key players were now entering the space with remarkably similar technologies.