The increasing problems of millions of HIV/AIDS orphans and the perceived need for an innovative and creative solution to tackle the psychological, social, and economic needs of vulnerable children tipped the scales in favor of accepting sociologist Kurt Mad?rin's proposal: Klaus Leisinger and Karin Schmitt of the Novartis Foundation for Sustainable Development gave Mad?rin the go-ahead for setting up a pilot program in Tanzania to address the psychosocial needs of children who had lost parents to AIDS. This case describes the pilot program in Tanzania, Novartis's role in creating it, and?in 2001?the launch of a Regional Psychosocial Support Initiative (REPSSI) to address the psychosocial problems on a wider scale. The Novartis Foundation and the other organizations involved had to assess different countries and determine which one would be the best headquarters for REPSSI, and they had to focus on creating a strong and effective organizational operation.